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Cataplexy pronunciation3/7/2023 On first night of dosing with calcium/magnesium/potassium/sodium oxybates, initiate at the same dose (gram for gram) and regimen as sodium oxybateĪmobarbital, calcium/magnesium/potassium/sodium oxybates.Įither increases effects of the other by pharmacodynamic synergism.Reduce initial dosage by one half of the original dosage per night, divided into 2 doses.Gradually titrate dose based on efficacy and tolerability unequal dosages may be required for some patients to achieve optimal treatment.≥45 kg: Initiate at ≤2.25 g HS and ≤2.25 g taken 2.5-4 hr later may increase at weekly intervals up to 0.75-g/dose not to exceed 4.5 g/dose.20 to <7 years: Safety and efficacy not established ≥7 years
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